Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein
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چکیده
منابع مشابه
Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein
Protein translocation into the endoplasmic reticulum is mediated by signal sequences that vary widely in primary structure. In vitro studies suggest that such signal sequence variations may correspond to subtly different functional properties. Whether comparable functional differences exist in vivo and are of sufficient magnitude to impact organism physiology is unknown. Here, we investigate th...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2010
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200911115